A few simple things can save grief in the long run when you take off on a long haul - or even to the next town over...
Check tire pressure every morning. Invest in a quality tire pressure gauge - don’t trust your life with those cheapo stick gauges.
Consider a windshield. Depending on your location, how fast you like to ride, the time of year and average air temperature, a windshield can make for a more comfortable ride. I know this because I didn’t have one - in the Nevada desert, the incoming air was a cooling relief; in Montana, it was brutal, cold, and felt like I was getting punched in the chest for hours on end.
Know where to find help. Before I left, I used the online yellow pages to make a list of Vespa dealerships and motorcycle repair shops along my route with addresses and phone numbers.
Let go of your worries. Stressing the whole time about what might go wrong defeats the purpose of your trip. Be aware and be safe, then let go and enjoy.